This work, by Dr. Qinghu Ren from The Institute for Genomic Research, includes the identification and characterization all...
This work, by Dr. Qinghu Ren from The Institute for Genomic Research, includes the identification and characterization all existing membrane transporters in those microorganisms and eukaryotic species for which extensive genome sequence data are available. For each organism, the complete set of membrane transport systems was identified and classified into different types and families according to putative membrane topology, protein family, bioenergetics, and substrate specificities. This is the only database devoted to the identification and classification of all transporter homologues in complete genomes, as well as providing comparative and phylogenetic tools for analyzing data. I definitely recommend to the research and academic community as well as college and graduate student as an excellent learning and reference material.Technical Remarks: Dr. Qinghu Ren?s marvelous work requires strong background in both molecular biology and computer science. TransportDB is a relational database which will be regularly updated with data obtained from newly sequenced genomes. User-friendly web pages provide interfaces to easily access, query, and download the data. Additional features, such as a BLAST search tool against known transporter protein sequences, comparison of transport systems from different organisms, and phylogenetic trees of individual transporter families are also provided.