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MERLOT II


    

Comment


Material:

Actin-myosin crossbridge animation

Rating: No Rating (Comment only)
Used in Course: Not used in course
Submitted by: Nancy J. Pelaez (Faculty), Dec 11, 2001
Comment: I am VERY concerned about the global approval of this model in both the peer
review and the user comment. This model was presented by a plenary speaker at
the Experimental Biology 2001 meeting as an example of a representation that
does not always fit the data about how muscle works. As with most models, this
one has serious limitations and it should not be taught as fact. An alternative
source of information comes from muscle physiologists. Refer to the MERLOT
site called "Video of myosin v movement along actin" and the research group that
presents an alternative model at the bottom of the page at
http://www.mrc-lmb.cam.ac.uk/myosin/motility/XBcycle.html Perhaps students
should be asked to compare and contrast the models to decide which model best
matches what we know about actin-myosin interactions ( a critical thinking
approach that would leave student with a more realistic view to the limits of
our understanding).

Technical Remarks:

The animations at the links listed above are stacks of gif images.