Alzheimer’s disease is the most common cause of age-related dementia. Alzheimer’s disease presents with irreversible cognitive decline, which commences as insidious short-term memory dysfunction and gradually spreads to other cognitive domains, rendering patients mute and non-ambulatory after 10-15 years of progressive course. Unfortunately, there are neither effective preventive measures nor efficacious treatments available for this devastating disease. Such a situation undoubtedly calls for the diversification of druggable targets for Alzheimer’s disease and a search for poly-targets or drug combination therapeutic strategies. Contributed by an assembly of clinicians and translational and basic research scientists, this book intends to provide an overview of the current state and future perspectives of Alzheimer’s disease drug discovery. It covers the underlying pathogenic mechanisms of Alzheimer’s disease and provides a review of Aβ amyloid- and τ protein-targeted immunotherapies, and peptide inhibitors for anti-Aβ amyloidosis. In addition, it also examines therapeutic potentials of various Alzheimer’s disease drug targets such as brain metal homeostasis, protein kinase C, the blood-brain barrier, epigenetic therapies, as well as discusses chimeric conjugates, multifunctional ligands, and natural products as interventional approaches. This book will be valuable to healthcare professionals caring for patients, researchers and interested readers as it will provoke thoughts about identifying novel and more efficacious therapeutic agents for Alzheimer’s disease and related dementias.
Type of Material:
Open (Access) Textbook
Recommended Uses:
Textbook for assignments at the graduate level
Reference book for professionals
Homework, content reading
Technical Requirements:
Accessed via major browser. Easily accessible.
Identify Major Learning Goals:
Overall Goals:
Addresses dementia and other memory related conditions.
Consider treatments for persons with Alzheimer's and memory related conditions.
After completion of the textbook, engaged learners will
1. Describe the pathophysiology of Alzheimer's.
2. Explain pharmacology treatments for dementia.
Target Student Population:
Graduate School
Professional
Prerequisite Knowledge or Skills:
Pathophysiology and pharmacology is helpful
Content Quality
Rating:
Strengths:
The book includes contributors from around the world to advance the knowledge of treatment for Alzheimer’s disease.
Information is relevant for current practice and research.
Content is in detail and concepts are fully developed.
Potential Effectiveness as a Teaching Tool
Rating:
Strengths:
This book builds on current knowledge and updates the pharmacology for Alzheimer’s disease.
Diagrams and pictures are helpful in the explanations of pharmacokinetics and dynamics.
Format of information is appropriate for learrning and content.
Ease of Use for Both Students and Faculty
Rating:
Strengths:
Easy to access using web browser and a laptop.
Navigation is also easy using clearly identified tabs.
The book is broken down by chapter so one does not need to scroll through the entire book to get to a chapter.
Content is easy to access.
Other Issues and Comments:
Fabulous textbook for a pharmacology class at the graduate level.
Creative Commons:
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