Biochemistry is a science concerned with the question “how does this work? Or how does it do that?” Of course this is at a molecular level and as such can be very hard to visualize. Therefore you need to know how to look at, interpret and critically assess data.
Course Outcomes, Competencies, and Supplemental Competencies: A. Explain the fundamental biochemistry behind veterinary, medical or dental topics and issues. 1. Relate the roles of real meaning and use of biochemistry through application of biochemistry using context specific discussion of clinical cases. 2. Analyze how living things obtain energy from food, the chemical basis of heredity, what fundamental changes occur in disease, and related issues. B. Demonstrates the fundamental principles of protein structure and function, carbohydrate and lipid metabolism. 1. Develop and express a general overview of the life of a protein as: synthesis, folding, modification, function, degradation. 2. Compare and contrast the macromolecules that make up life. C. Demonstrate the fundamental principle of enzyme mechanisms, enzyme kinetics, biochemical energetics, membranes, nucleic acid and protein metabolism. 1. Compare and contrast enzymes and catalysts 2. Relate the roles of thermodynamics and kinetics to the rates of chemical reactions. 3. Define and apply the concepts of the Hierarchical Nature of Metabolism including but not limited to metabolic pathway, Krebs cycle, Citric Acid Cycle. D. Explain nucleic acid biochemistry, including DNA replication and repair, synthesis of RNA (transcription), synthesis of proteins (translation), and regulation of gene expression. 1. Describe and relate the differences between the structures of DNA and RNA 2. Describe and demonstrate how information transferred and the nucleotide triplets of DNA and RNA molecules that carry genetic information in living cells. 3. Examine the roles of DNA and RNA in replication and repair 4. Examine the role of RNA in synthesis of RNA 5. Examine the roles of nucleic acids in synthesis of proteins 6. Consider the role of gene expression on physical expression. E. Explain the interdependence of biochemical pathways, pathogenesis and additional new topics. 1. Describe and relate the differences between chemical and physical changes. 2. List, name, and relate aspects of metabolic pathways.
Assessment: 1. Quizzes There will be quizzes that you will need to accomplish throughout the course of the semester. Each quiz will cover a specific portion of the lectures and this information will be made available to you. You will have two attempts for each quiz and as such you should be able to do quite well on them. You will be given access to the quizzes on the first day of class. See the class schedule for due dates of each quiz. 2. Exams/projects will be a combination of multiple choice, matching and short answers. Each exam will be made available to you online in a one-week window. This window allows you the freedom to schedule a time that works best for you to accomplish the assignment. Please see the schedule for when each exam will be available and what it will cover. All exams are to be completed through Examity. Use Examity, an online proctoring service, requiring a webcam and microphone. The cost for online proctoring is included in the cost of the course. Each exam will cover a specific portion of the lectures and this information will be made available to you. You will have two attempts for each quiz and as such you should be able to do quite well on them. You will be given access to the quizzes on the first day of class. See the class schedule for due dates of each quiz. 3. There will also be Discussion Boards based on Case Studies where you will apply what you are learning. These will be critical thinking questions. I do not expect that you will get them correct but the idea is that you will be picking apart the information and analyzing what information you have and, interpreting it and critically assessing the data. The objective of studying is to learn the material that is being presented. Exams are designed to assess whether or not you have learned.