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According to the author, "The book is intended as a help for students and researchers in the biomedical fields, enabling them to choose the best model for their dose-response data obtained from wet-lab experiments. The focus is on how to interpret and handle dose-response data, with a recommendation to down-play analytical methods...
According to the author, "The book is intended as a help for students and researchers in the biomedical fields, enabling them to choose the best model for their dose-response data obtained from wet-lab experiments. The focus is on how to interpret and handle dose-response data, with a recommendation to down-play analytical methods developed before the era of personal computers, such as the Lineweaver–Burk and Scatchard data conversion, the null-methods by Gaddum and Schild, or the use of meaningless mathematical manipulations, as for instance the implementation of a Hill-exponentiation. Instead, when fishing for system constants, the readers learn how to get access to the free-way of analytical tools that offer forward formulated physical functions to be fixed with non-linear fitting procedures. The approach I have taken is different from that of many other textbooks on the analysis of equilibrium dose-responses, which follow in the tradition of data-linearization developed more than 70 years ago. A book in point is Segel's ‘Enzyme kinetics’ (1975), reissued as a non-revised edition in 1993 and still considered a standard textbook on enzyme kinetics: it lacks almost completely in analysis of the so-called two-state models."