The Cochrane Library has led the way in providing critical appraisal of both carmustine wafer implants (Gliadel®) and Temozolomide therapies, underpinning their integration into clinical practice. The future of neuro-oncology is likely to involve the development of individualised therapy and the use of more sophisticated operative techniques; translating these advances into improved clinical outcomes, including greater emphasis on quality of life, will require building on the foundation of the reviews in this collection. Topics included on this webpage: Adjuvant treatment of anaplastic oligodendrogliomas and oligoastrocytomas; Biopsy versus resection for high grade glioma; Chemotherapeutic wafers for high grade glioma; Temozolomide for high grade glioma; High-dose chemotherapy and autologous haematopoietic stem cell rescue for children with high-risk neuroblastoma; nterventions for the treatment of metastatic extradural spinal cord compression in adults; Surgical resection and whole brain radiation therapy versus whole brain radiation therapy alone for single brain metastases; Whole brain radiotherapy for the treatment of multiple brain metastases; Whole brain radiation therapy (WBRT) alone versus WBRT and radiosurgery for the treatment of brain metastases; and Pharmacological treatment of depression in patients with a primary brain tumour.