This 155-page manual is comprised of two types of learning activities: 1) free response fill-in-the blank questions focused of the facts and principles of neuroanatomy and neurophysiology that underpin the neurologic examination and specifically developed exercises that demonstrate how the facts and principles are related to the particular tests and procedures that comprise the neurologic examination. Free response questions form the bulk of the Neuroscience Review section of each chapter and are intended as a review of information previously or concurrently being learned regarding the structure, function and organization of the nervous system. Some questions focus on anatomical or physiological facts and relationships that help explain why certain techniques are performed as they are, such as why non-nociceptive tactile stimuli are required in order to activate nerve impulse transmission in the lemniscal system. Other questions are intended to revisit facts and concepts that are needed to properly interpret the elicited findings. 2) The Application Exercises of each chapter are designed to demonstrate how neuroanatomical and neurophysiological information is used in the design of particular clinical tests of neurologic function. The application exercises are also intended to help users learn how to perform and become comfortable with the various clinical maneuvers and tests that comprise the routine neurologic examination. An important outcome of performing these exercises is that, as a member of a learning group, each individual has the opportunity to experience the neurologic examination from the point of view of the subject (patient)—an experience that arguably provides insight and understanding that can be gained in no other way.