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Uncovering signalling differences between primary and transformed hepatocytes using cell-specific logic-based pathway models

Uncovering signalling differences between primary and transformed hepatocytes using cell-specific logic-based pathway models

This video was recorded at Cancer Bioinformatics Workshop, Cambridge 2010. The last years have witnessed remarkable progress in the identification of oncogenes and the signaling networks in which they operate. Pathway maps summarizing literature knowledge are widespread and useful, but they do not allow prediction of pathway operation and do not usually include cell-type specific information. This is a critical limitation because it is precisely these differences between normal and diseased cells that are targeted for therapeutic intervention. We have developed an efficient method to construct cell-specific logic models of signaling networks based on generic pathway maps and high-throughput phosphoproteomics data. These methods are embedded in the MATLAB toolbox CellNetOptimizer, which... Show More

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