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Theory of macromolecular transport through protein channels and nanopores

This video was recorded at Kolokviji na Institutu "Jožef Stefan". An understanding of the ubiquitous phenomenon of translocation of electrically charged macromolecules through narrow channels requires an adequate description of polyelectrolyte dynamics, electrolyte dynamics, and hydrodynamics, and the confinement effects from the charge-decorated pores. The biophysics of polyelectrolyte translocation process will be discussed using concepts from polyelectrolyte physics and electrophysiology, against a background of single-molecule experiments. Specifically, the capture and threading of DNA/RNA and proteins through alpha-hemolysin channels and solid-state nanopores under an external electric field, and DNA ejection in bacteriophages will be discussed..

Keywords:: videolectures, ocwc, oec

Disciplines:

Science and Technology / Chemistry / Polymer and Macromolecular

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Material Type:: Presentation
Date Added to MERLOT:: February 10, 2015
Date Modified in MERLOT:: February 10, 2015
Author:: Murugappan Muthukumar, Department of Polymer Science and Engineering, University of Massachusetts Amherst
Submitter:: The Open Education Consortium
Primary Audience:: College General Ed, College Lower Division, College Upper Division
Technical Format:: Video

Mobile Compatibility:: Not specified at this time
Language:: English
Cost Involved:: No
Source Code Available:: No
Accessibility Information Available:: Unknown
Creative Commons:: This work is licensed under a Attribution-NonCommercial-NoDerivs 3.0 United States