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Systems Pharmacology: An Industry Perspective

Systems Pharmacology: An Industry Perspective

This video was recorded at 20th International Symposium on Microsomes and Drug Oxidations (MDO), Stuttgart 2014. Systems pharmacology is becoming a key tool for biotherapeutics drug discovery and development. Systems pharmacology utilizes mathematical models that describe the pharmacokinetics and pharmacodynamics (PK/PD) on a mechanistic level taking into account the relevant physiology. These models are used along the entire drug discovery and development process for hypothesis building, prediction, data integration and data analysis enabling informed decision making on a quantitative and mechanistic basis. The use of systems pharmacology can be seen as a natural consequence of the current trend developing biotherapeutics with increasingly complex mode of actions. For these cases, which... Show More


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