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The influence of space restriction on the formation and stability of polymorphic and amorphous forms

The influence of space restriction on the formation and stability of polymorphic and amorphous forms

This video was recorded at SLONANO conference, Ljubljana 2007. It is known from the classical nucleation theory that crystallization can only occur if critical nuclei are formed. Thus, there has to be enough space available for the formation of such nuclei. In the present work, we determined theoretical criteria that have to be satisfied for the occurence of a crystalline phase from a supersaturated solution in confinement conditions (e. g. resulting from entrapment of a drug solution into a porous matrix). Similar criteria were determined for the occurence of crystallization from amorphous or metastable polymorphic phases in confinement conditions. It was shown theoretically that spatial constraint can cause vitrification from solution or polymorph selection1. Metastable phases, which are... Show More

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