Chapter 1 Section 1: Introduction to Nutrition Basics

Macronutrients and Micronutrients

Nutritional Basics
Learning Objectives
  • Describe the relationship of macronutrients to health status
  • Identify micronutrients and their link to macronutrients and health
Content of the nutrition section and energy and energy calculation section adapted from Draper, Kainoa Fialkowski Revilla, and Titchenal (2020). Human Nutrition 2020e, University of Hawaii at Mānoa. LibreText. https://med.libretexts.org/Bookshelves/Nutrition/Human_Nutrition_2020e_(Hawaii)
Introduction:
Brief overview of what nutrients are to nutrition:
The foods we eat contain nutrients. Nutrients are substances required by the body to perform its basic functions. Nutrients must be obtained from our diet since the human body does not synthesize or produce them. Nutrients have one or more of three basic functions: they provide energy, contribute to body structure, and/or regulate chemical processes in the body. These basic functions allow us to detect and respond to environmental surroundings, move, excrete wastes, respire (breathe), grow, and reproduce. There are six classes of nutrients required for the body to function and maintain overall health. These are:
  • Carbohydrates
    1. Carbohydrate means "hydrated carbon", or carbon with water. Thus, carbohydrates are made up of carbon, hydrogen, and oxygen. Sucrose (table sugar) is an example of a commonly consumed carbohydrate. Some dietary examples of carbohydrates are whole-wheat bread, oatmeal, rice, sugary snacks/drinks, and pasta.
  • Lipids
    1. Lipids consist of fatty acids, triglycerides, phospholipids, and sterols (i.e. cholesterol). Lipids are also composed of carbon, hydrogen, and oxygen. Some dietary sources of lipids include oils, butter, and egg yolks.
  • Proteins
    1. Proteins are also made up of carbon, hydrogen, and oxygen, but they also contain nitrogen. Several dietary sources of protein include nuts, beans/legumes, skim milk, egg whites, and meat.
  • Water
    1. Water is made up of hydrogen and oxygen (H2O) and is the only macronutrient that doesn't provide energy.
  • Vitamins
    1. Organic compounds that are essential for normal physiologic processes in the body. These are part of the micronutrient category.
  • Minerals
    1. Elements (think periodic table) that are essential for normal physiological processes in the body. These part of the micronutrient category.
Foods also contain non-nutrients that may be harmful (such as natural toxins common in plant foods and additives like some dyes and preservatives) or beneficial (such as antioxidants).
Macronutrients
Nutrients that are needed in large amounts are called macronutrients. There are three classes of macronutrients: carbohydrates, lipids, and proteins. These can be metabolically processed into cellular energy. The energy from macronutrients comes from their chemical bonds. This chemical energy is converted into cellular energy that is then utilized to perform work, allowing our bodies to conduct their basic functions. A unit of measurement of food energy is the calorie. On nutrition food labels the amount given for “calories” is equivalent to each calorie multiplied by one thousand. A kilocalorie (one thousand calories, denoted with a small “c”) is synonymous with the “Calorie” (with a capital “C”) on nutrition food labels. Water is also a macronutrient in the sense that you require a large amount of it, but unlike the other macronutrients, it does not yield calories.
Carbohydrates
Carbohydrates are molecules composed of carbon, hydrogen, and oxygen. The major food sources of carbohydrates are grains, milk, fruits, and starchy vegetables, like potatoes. Non-starchy vegetables also contain carbohydrates, but in lesser quantities. Carbohydrates are broadly classified into two forms based on their chemical structure: simple carbohydrates, often called simple sugars; and complex carbohydrates.
  • Simple carbohydrates consist of one or two basic units. Examples of simple sugars include sucrose, the type of sugar you would have in a bowl on the breakfast table, and glucose, the type of sugar that circulates in your blood.
  • Complex carbohydrates are long chains of simple sugars that can be unbranched or branched. During digestion, the body breaks down digestible complex carbohydrates to simple sugars, mostly glucose. Glucose is then transported to all our cells where it is stored, used to make energy, or used to build macromolecules. Fiber is also a complex carbohydrate, but it cannot be broken down by digestive enzymes in the human intestine. As a result, it passes through the digestive tract undigested unless the bacteria that inhabit the colon or large intestine break it down.
One gram of digestible carbohydrates yields four kilocalories of energy for the cells in the body to perform work. In addition to providing energy and serving as building blocks for bigger macromolecules, carbohydrates are essential for proper functioning of the nervous system, heart, and kidneys. As mentioned, glucose can be stored in the body for future use. In humans, the storage molecule of carbohydrates is called glycogen, and in plants, it is known as starch. Glycogen and starch are complex carbohydrates.

Lipids
Lipids are also a family of molecules composed of carbon, hydrogen, and oxygen, but unlike carbohydrates, they are insoluble in water. Lipids are found predominantly in butter, oils, meats, dairy products, nuts, and seeds, and in many processed foods. The three main types of lipids are triglycerides (triacylglycerols), phospholipids, and sterols. The main job of lipids is to provide or store energy. Lipids provide more energy per gram than carbohydrates (nine kilocalories per gram of lipids versus four kilocalories per gram of carbohydrates). In addition to energy storage, lipids serve as a major component of cell membranes, surround and protect organs (in fat-storing tissues), provide insulation to aid in temperature regulation, and regulate many other functions in the body.

Proteins
Proteins are macromolecules composed of chains of subunits called amino acids. Amino acids are simple subunits composed of carbon, oxygen, hydrogen, and nitrogen. Food sources of proteins include meats, dairy products, seafood, and a variety of different plant-based foods, most notably soy. The word protein comes from a Greek word meaning “of primary importance,” which is an apt description of these macronutrients; they are also known colloquially as the “workhorses” of life. Proteins provide four kilocalories of energy per gram; however, providing energy is not protein’s most important function. Proteins provide structure to bones, muscles and skin, and play a role in conducting most of the chemical reactions that take place in the body. Scientists estimate that greater than one-hundred thousand different proteins exist within the human body. The genetic codes in DNA are basically protein recipes that determine the order in which 20 different amino acids are bound together to make thousands of specific proteins.

Water
There is one other nutrient that we must have in large quantities: water. Water does not contain carbon but is composed of two hydrogens and one oxygen per molecule of water. More than 60 percent of your total body weight is water. Without it, nothing could be transported in or out of the body, chemical reactions would not occur, organs would not be cushioned, and body temperature would fluctuate widely. On average, an adult consumes just over two liters of water per day from food and drink combined. Since water is so critical for life’s basic processes, the amount of water input and output is supremely important, a topic we will explore in detail later in this section.

Micronutrients
Micronutrients are nutrients required by the body in lesser amounts but are still essential for carrying out bodily functions. Micronutrients include all the essential minerals and vitamins. There are sixteen essential minerals and thirteen vitamins (Table 1 & Table 1.2). In contrast to carbohydrates, lipids, and proteins, micronutrients are not sources of energy (calories), but they assist in the process as cofactors or components of enzymes (i.e., coenzymes). Enzymes are proteins that catalyze chemical reactions in the body and are involved in all aspects of body functions from producing energy, to digesting nutrients, to building macromolecules. Micronutrients play many essential roles in the body.

Minerals
Minerals are solid inorganic substances that form crystals and are classified depending on how much of them we need. Trace minerals, such as molybdenum, selenium, zinc, iron, and iodine, are only required in a few milligrams or less. Macrominerals, such as calcium, magnesium, potassium, sodium, and phosphorus, are required in hundreds of milligrams. Many minerals are critical for enzyme function, others are used to maintain fluid balance, build bone tissue, synthesize hormones, transmit nerve impulses, contract and relax muscles, and protect against harmful free radicals in the body that can cause health problems such as cancer.

Table 1: Major minerals
Mineral SourceRDAFunctionDeficiency effects
CalciumDairy products, dark green leafy vegetables, blackstrap molasses, nuts, brewer’s yeast, some fish1000 mgBone structure and health; nerve and muscle functions, especially cardiac functionSlow growth, weak and brittle bones
PotassiumMeats, some fish, fruits, vegetables, legumes, dairy products4700 mgNerve and muscle function; acts as an electrolyteHypokalemia: weakness, fatigue, muscle cramping, gastrointestinal problems, cardiac problems
PhosphorusMeat, Milk700mgBone formation, metabolism, ATP productionRare
SodiumTable salt, milk, beets, celery, processed foods2300 mgBlood pressure, blood volume, muscle and nerve functionRare
MagnesiumWhole grains, nuts, leafy green vegetables310-420 mgEnzyme activation, production of energy, regulation of other nutrientsAgitation, anxiety, sleep problems, nausea and vomiting, abnormal heart rhythms, low blood pressure, muscular problems
ChlorideMost foods, salt, vegetables, especially seaweed, tomatoes, lettuce, celery, olives2300 mgBalance of body fluids, digestionLoss of appetite, muscle cramps


Table 1.2 Trace Minerals

MineralSourceRDAFunctionDeficiency effect
IronMeat, poultry, fish, shellfish, legumes, nuts, seeds, whole grains, dark leafy green vegetables8–18 mgTransport of oxygen in blood, production of ATPTransport of oxygen in blood, production of ATP
ZincMeat, fish, poultry, cheese, shellfish8-11 mgImmunity, reproduction, growth, blood clotting, insulin and thyroid functionLoss of appetite, poor growth, weight loss, skin problems, hair loss, vision problems, lack of taste or smell
CopperSeafood, organ meats, nuts, legumes, chocolate, enriched breads and cereals, some fruits and vegetables900 µgRed blood cell production, nerve and immune system function, collagen formation, acts as an antioxidantAnemia, low body temperature, bone fractures, low white blood cell concentration, irregular heartbeat, thyroid problems
IodineFish, shellfish, garlic, lima beans, sesame seeds, soybeans, dark leafy green vegetables150 µgThyroid functionHypothyroidism: fatigue, weight gain, dry skin, temperature sensitivity
SulfurEggs, meat, poultry, fish, legumesNoneComponent of amino acidsProtein deficiency
FluorideFluoridated water3-4 mgMaintenance of bone and tooth structureIncreased cavities, weak bones and teeth
ManganeseNuts, seeds, whole grains, legumes1.8 - 2.3 mgFormation of connective tissue and bones, blood clotting, sex hormone development, metabolism, brain and nerve functionInfertility, bone malformation, weakness, seizures
CobaltFish, nuts, leafy green vegetables, whole grainsNoneComponent of B12None
SeleniumBrewer’s yeast, wheat germ, liver, butter, fish, shellfish, whole grains55 µgAntioxidant, thyroid function, immune system functionMuscle pain
ChromiumWhole grains, lean meats, cheese, black pepper, thyme, brewer’s yeast25–35 µgInsulin functionHigh blood sugar, triglyceride, and cholesterol levels
MolybdenumLegumes, whole grains, nuts45 µgCofactor for enzymesRare

 https://openstax.org/books/anatomy-and-physiology/pages/24-7-nutrition-and-diet

Vitamins
The thirteen vitamins are categorized as either water-soluble or fat-soluble. Vitamins are required to perform many functions in the body such as making red blood cells, synthesizing bone tissue, and playing a role in normal vision, nervous system function, and immune system function (Table 2 & Table 2.1).

Table 2     Water soluble vitamins
Water soluble vitamins
Function


Vitamin C Collagen synthesis, antioxidant
Vitamin B complex's
Thiamine    B1 Coenzyme, energy metabolism assistance
Riboflavin    B2 Coenzyme, energy metabolism assistance
Niacin          B3 Coenzyme, energy metabolism assistance
Pantothenic acid    B5 Coenzyme, energy metabolism assistance
Pyridoxine    B6 Coenzyme,  amino acid synthesis assistance
Biotin   B7 Coenzyme, amino acid and fatty acid metabolism
Folate   B9 Coenzyme, essential for growth
Cobalamin   B12 Coenzyme, red blood cell synthesis

 

Table 2.1 Fat Soluble Vitamins

Fat soluble vitaminFunction


Vitamin AVision, reproduction, immune system function
Vitamin DBone and teeth health maintenance, immune system function
Vitamin EAntioxidant, cell membrane protection
Vitamin KBone and teeth health maintenance, blood clotting