Amyotrophic lateral sclerosis is a fatal, progressive neurodegenerative disorder characterized by motor neuron cell death in the brain and spinal cord. The typical disease symptom is the rapid loss of muscle control, which eventually leads to the complete paralysis of voluntary muscles of the entire body. There is no curative treatment for amyotrophic lateral sclerosis. The rarity of the disease and the difficulties in accurate early diagnosis are the major challenges in the proper understanding of the disease and the development of curative therapy. This book brings together a team of experts, both clinicians and basic scientists, to provide a comprehensive understanding of amyotrophic lateral sclerosis, challenges, and approaches to combat this devastating disease. The clinical chapters provide excellent views of diagnosis, pathology, management, and the problem of diagnostic delay. The basic science chapters provide a comprehensive description of pathomechanisms and therapies with emphasis on dysfunctional astrocytes, impaired synaptic transmission, defective axonal transport, biomarkers, cell-based therapies, and gut microbiota. The book is primarily aimed at clinicians and basic scientists; however, it will likely be of interest to a wide audience interested in amyotrophic lateral sclerosis.
Type of Material:
Open (Access) Textbook
Recommended Uses:
lecturers to prepare a lecture
required or recommended reading
self-directed study to
supplemental resource
Technical Requirements:
Internet access and web browser
Microsft edge was used to access the resource
Also used Chrome with no difficulty to access the resource
Identify Major Learning Goals:
After completing this activity, the active participant will:
Describe the clinical manifestation and management of amyotrophic lateral sclerosis.
Explain the diagnosis process and factors which affect diagnosis delay in amyotrophic lateral sclerosis.
Discuss the role of astrocytes in amyotrophic lateral sclerosis. ·
Explain synaptic transmission and motoneuron excitability defects in amyotrophic lateral sclerosis.
Describe axonal transport and local translation of mRNA in amyotrophic lateral sclerosis.
Discuss the role of blood-based biomarkers for amyotrophic lateral sclerosis.
Discuss the promises and challenges of cell-based research and therapy for amyotrophic lateral sclerosis.
Discuss the potential imbalance of gut microbiota as a risk factor for amyotrophic lateral sclerosis.
Students in the following fields: nursing, medicine, physiotherapy and occupational therapy
Scientists
Persons diagnosed with amyotrophic lateral sclerosis
Prerequisite Knowledge or Skills:
Anatomy and physiology of the nervous system
Content Quality
Rating:
Strengths:
The material is presented in each chapter clearly explains the various topics.
The book includes a collaboration of current research from experts in the field of neurology and research.
The combination of written and pictorial representation allows the reading the understand what is being explained.
Each chapter is well referenced and provided hyperlink whereby readers can do further reading.
The abstract at the being of each chapter is an added bonus since readers can have an overall view of the chapter.
Potential Effectiveness as a Teaching Tool
Rating:
Strengths:
Material can be used in different fields of healthcare
The material is a good way to provide EBP
Appeals to different learning styles
Material provides substantial information
Each chapter can be used as a separate lecture
can be used to facilitate to support course assignments
Concerns:
The learning objectives are not clearly identified; only after reading the abstract the reader will have an idea of what the book entails.
There is no indication of pre-required knowledge.
Ease of Use for Both Students and Faculty
Rating:
Strengths:
Links are working and easily accessible
Easy to access and download
All pop outs are functional
Links to references are functional
Information is accurate
The layout is consistent throughtout
Available in a downloadable pdf format and PubReader
The ability to search the book by inputting terms
Use the link to find the accessibility for visual impairments and then click Pub Reader in the upper right hand link and it will read the book out loud: https://www.ncbi.nlm.nih.gov/books/NBK573426/
Images have word discriptions
Creative Commons:
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