This interactive module uses the central dogma as a model for exploring how modern molecular biology technologies can be used to treat different genetic conditions. The Click & Learn describes different steps in the pathways from gene to RNA to protein. It also provides information about a treatment strategy that targets each step, and an example of a genetic disease for which that strategy has been shown to work, either in experimental models or human clinical trials. The examples include treatments for cystic fibrosis, sickle cell disease, and Huntington’s disease, and are supplemented by video clips from the documentary The Gene Doctors, an HHMI Tangled Bank Studios Production.
Type of Material:
Animation or Simulation
Recommended Uses:
As a self-paced homework or lab activity.
Technical Requirements:
None.
Identify Major Learning Goals:
Student Learning Targets
Describe the steps of gene expression and what happens in each.
Describe how different types of genetic medicine can be used to treat various genetic conditions.
Apply the information provided to propose a genetic medicine that could be used to treat a different disease.
Target Student Population:
College General Ed, High school
Prerequisite Knowledge or Skills:
Familiarity with molecular biology vocabulary.
Content Quality
Rating:
Strengths:
The content is accurate and high quality.
The content is supported by high quality animations.
The resource provides a good basic background about the concept.
Links to related resources are provided.
Concerns:
None.
Potential Effectiveness as a Teaching Tool
Rating:
Strengths:
The resource identifies the student learning targets (objectives).
The resource demonstrates relationships between concepts and reinforces concepts progressively.
Real-life scenarios in the form of Case Studies provide students with activities that will engage them.
Instructions on how to modify the resource in Google folder is provided.
Links to related resources are available.
There is some interactivity, increasing engagement.
There are apps available for computers.
The animations are attractive and engaging.
The topic is a basic concept in biology and is well-covered in the resource both conceptually and in the details.
Resources, including student worksheets, are provided.
Connections to common curricular standards are provided.
Information on how long the activity will take, accessibility standards, key terms in the activity, and terms of usage by an instructor are provided.
Concerns:
None.
Ease of Use for Both Students and Faculty
Rating:
Strengths:
The resource opens easily in any browser.
The activity is intuitive to navigate, modify, and complete.
The interactivity is intuitive.
A transcript is provided.
Spanish language versions of the resources are provided.
Accessibility and web standards are met.
Concerns:
None.
Creative Commons:
Search by ISBN?
It looks like you have entered an ISBN number. Would you like to search using what you have
entered as an ISBN number?
Searching for Members?
You entered an email address. Would you like to search for members? Click Yes to continue. If no, materials will be displayed first. You can refine your search with the options on the left of the results page.
Searching for Members?
You entered an email address. Would you like to search for members? Click Yes to continue. If no, materials will be displayed first. You can refine your search with the options on the left of the results page.
