“Visualizing the Synthesis of Thyroid Hormones” is an animated video presentation designed to help students visualize the steps in thyroid hormone synthesis. The material describes the complex process of thyroid hormone synthesis from the step of iodide trapping to the attachment of hormone on the peripheral receptors. Topics covered include: 1) iodide trapping, 2) oxidation of iodide, 3) synthesis of thyroglobulin 4) iodination of tyrosine, 5) conjugation of T1 and T2, 6) endocytosis and digestion of colloid, 7) secretion of thyroid hormones, 8) conversion of T4 to T3 at target tissues, and 9) binding of T3 to nuclear receptors. The presentation is short, lasting 7 minutes and 43 seconds. The target audience is college or graduate students.
Type of Material:
This material is provided as an animated presentation.
This presentation could be used in the “flipped classroom” method of teaching where students can preview this presentation prior to coming to class. This presentation could be used during a lecture or could be used as a supplemental resource for students.
Technical requirements include Adobe Flash Player. At the time of this review, the material was best viewed in Mozilla Firefox 19.0+, Internet Explorer 9.0+, and Google Chrome.
Identify Major Learning Goals:
Students will be able to describe the steps involved in the synthesis of thyroid hormones T3 and T4. Users will also be able to describe a thyroid follicle and explain the step by step process of thyroid hormone production.
Target Student Population:
This material can be used at all levels of undergraduate and graduate education.
Prerequisite Knowledge or Skills:
Although no prerequisites are mentioned for this material, better understanding would be achieved with some college level understanding of human physiology.
Evaluation and Observation
The content in the videos is accurate and up-to-date
The animations are high quality and presentation is very clear
The material efficiently demonstrates the concepts and includes an adequate amount of material
The content is core material for a physiology class
The presentation provides a complete and thorough demonstration of thyroid hormone synthesis
The presentation is informed by scholarship and is self-contained
At the time of this review there were no concerns about content quality
Potential Effectiveness as a Teaching Tool
The presentation appeals to multiple senses; there is text to read, audio, and visual animations
Material builds upon prior concepts
The presentation is clear and easy to follow
Simple and clear animation allows easy understanding of the core concepts
Very efficient and facilitates learning
The students can go through the presentation at their own pace and re-listen to sections
The presentation contains a “search” box where students can locate certain topics
There are no objectives listed
Quiz questions at the completion of the presentation would be useful for student self-assessment to determine if they understand the material
Site does not provide additional resources
The presentation is not interactive
Ease of Use for Both Students and Faculty
The presentation is visually appealing
The site is easy to navigate and engaging
The presentation is easy to use
The site is of high quality design
The stop/pause button doesn’t always work; sometimes the video continues to play
Other Issues and Comments:
Good work! The author of this site is encouraged to submit additional materials for the learning community.