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The object of the course is to teach students an approach to the study of pharmacologic agents. It is not intended to be a review of the pharmacopoeia. The focus is on the basic principles of biophysics, biochemistry and physiology, as related to the mechanisms of drug action, biodistribution and metabolism. The course consists of lectures and student-led case discussions. Topics covered include: mechanisms of drug action, dose-response relations, pharmacokinetics, drug delivery systems, drug metabolism, toxicity of pharmacological agents, drug interaction and substance abuse. Selected agents and classes of agents are examined in detail. The course was taught is 2005; however, the concepts should be current.

Lecturers Prof. Keith Baker Dr. Mark Dershwitz Harold Demonaco Dr. Daniel Kohane Dr. Donald Kufe Prof. Robert Langer Dr. Robert Lees Dr. Robert Rubin Dr. Jeremy Ruskin Prof. Thomas Spitzer Prof. Carol Walsh Dr. Michael Weinblatt Dr. Warren Zapol

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