Material Detail

Interactive 3D molecular visualization with immediate-feedback quiz. Following an Introduction to Molecular Visualization (elsewhere), there are six chapters with a total of 44 rotatable views of hemoglobin molecular structure. Suitable for illustrating a lecture, or for students to use. Text visible in a lecture describes main points of each view. Details that a lecturer may wish to know about when preparing are hidden until requested.

1. Introduction to Molecular Visualization (elsewhere) describes atomic representations, slabbing, simplified schematic representations for protein backbone traces, ribbons, disulfide bonds, and color schemes for macromolecules.
2. Hemoglobin and Heme: The (αβ)₂ four-chain protein molecule. Heme with iron that binds histidine and molecular oxygen.
3. Hemoglobin secondary structure: Alpha helices and their hydrogen bonds.
4. Amphipathic alpha helices and the hydrophobic pocket that accomodates heme.
5. Hydrophobicity, polarity and charge: Hydrophobic cores, surface charges and salt bridges.
6. Regulation of oxygen binding: Animated morphs of the R<-->T transition at the heme level, and the protein tetramer level. Binding of 2,3-diphosphoglycerate.
7. Sickle hemoglobin. The disease, sickling of red blood cells, the mutation to valine 6, how deoxygenated molecules stick together forming fibers.

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