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Author summary Designing experiments is obligatory in the biosciences to valorize their scientific outcome. When the experiments are expensive, unfortunately, in practice often the costs emerge to be showstoppers. In this situation the question arises: How to get the most out of the experiment for your invest in terms of time and money? We approach this question by formulating the design task as a multiple-criteria optimization problem. Its solution produces a set of Pareto-optimal design proposals that feature the trade-off between information gain, as measured by different metrics, and the costs. Then, exploration of the design proposals allows us to make the best decision on information-economic experiments under given circumstances. Implemented in the field of isotope-based metabolic flux analysis, practical application of the Pareto approach provides detailed insight into the tight interplay of plenty of information carriers and cost factors. Supported by an innovative tailored visual representation scheme, the investigator is enabled to explore the options before conducting the experiment. With a practical showcase at hand, our computational study highlights the benefits of incorporating multiple information criteria apart from the costs, balancing the shortcomings of conventional single-objective experimental design strategies.

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