Material Detail

Video Tutorial with Quiz & open-ended questions: Major Histocompatibility Complex (MHC) molecular structure and how it supports defense functions. (To help with watching this you might like an introduction to how protein molecules are shown by computers.)

CONTENTS

• Main functions of MHC classes I and II with CD8 and CD4 T lymphocytes.
• Cells expressing each class of MHC.
• Sources of peptides in the proteasome and lysosome.
• Reduction of MHC I on virus-infected cells inviting Natural Killer Cells.
• Severe immunodeficiency resulting from genetic absence of MHC II.
• Structure of MHC class I: Alpha chain and domains, beta-2 microglobulin, peptide in cleft with closed ends, papain cleavage locus, CD8 binding site, secondary structure.
• Evolutionary conservation of CD8 binding site and residues binding peptide anchor residues and ends. Variability in sequences of lips of the cleft due to alleles needed to accomodate wide range of peptides.
• Peptide side chains buried (anchor residues) vs. exposed to T cell surveillance.
• Comparison of two different peptides in MHC I from perspective of T cells.
• Structure of MHC class II: Alpha and beta chains, peptide in cleft with open ends.

QUESTIONS AND ANSWERS

• Quiz with immediate feedback.
• Worksheet with open-ended questions for discussion.
• Suggestions for teachers, including answers to open-ended questions.

THE PRIMARY HOME for this tutorial and others on DNA, Hemoglobin, etc. is MolviZ.Org

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