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'"The Sign of the Four" is one of Sir Arthur Conan Doyle's Sherlock Homes mystery stories. It was the second book to be published and one of the 4 full length novels.
In the story, Sherock Holmes and the smitten Dr. John Watson try to defeat a peg-legged man and his dwarf assistant.
At the outset of the novel Doctor Watson states that he has been watching Holmes takes cocaine three times a day for many months. Watson's reluctance to oppose Holmes is finally overcome and he confronts his friend about the potential ill effects of this prolonged usage.
Holmes explains that he finds the drug stimulates and clarifies his mind and that without work to challenge his mental faculties he becomes bored with day to day life.'