Infrastructure forms the backbone of our society – from roads and railways to waterworks and ports – as critical part of vital systems for mobility, water and space. But that backbone is under strain. Ageing systems, climate change and scarce resources force us to rethink fundamentally how we design, use and value infrastructure. This Design Guide starts with one urgent question: how can we make infrastructure future-proof in a world of uncertainty? It introduces integrated approaches in which design, engineering, policy and societal value come together through a wide range of inspiring examples related to urban and regional accessibility and development, spatial quality, flood protection, and ecological restoration. The book demonstrates how infrastructure can be more than merely a functional system. It becomes a driver of societal value and prosperity, and a strategic instrument that connects quality of life, sustainability and economic development. This Design Guide offers a clear conceptual framework to understand and design infrastructure that is not only more efficient, but also more sustainable, inclusive and meaningful. Drawn from thematical insights and lessons, and applicable methods, techniques and strategies by a broad range of scientists and professionals of practice with a background architecture, urban development and design, landscape architecture, civil engineering, economics, governance or policy. A substantial and indispensable guide for designers, engineers and policymakers committed to shaping the infrastructure and the society of tomorrow.