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Circadian metabolomics from mice and men: Insights for mechanism and medicine

Circadian metabolomics from mice and men: Insights for mechanism and medicine

This video was recorded at 20th International Symposium on Microsomes and Drug Oxidations (MDO), Stuttgart 2014. A biological "circadian" clock regulates nearly all aspects of mammalian physiology in accordance with the solar day. Not only sleep and wake, but also mood and cognition, circulation and cardiac function, and nearly all aspects of digestion and detoxication are under circadian control. This diurnal programming is exerted through both hormonal and cell-autonomous mechanisms at multiple levels. For the whole organism, our laboratory has demonstrated global circadian control of the human metabolome in blood and saliva, even in the absence of diurnal sleep, wake, and food intake. Nevertheless, sleep also plays an independent role in regulating global metabolic function, because... Show More
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