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Integration of genome-wide data to infer genetic networks

Integration of genome-wide data to infer genetic networks

This video was recorded at 1st International Workshop on Machine Learning in Systems Biology (MLSB), Evry 2007. To comprehend biology as a system, one needs to analyze the structure and dynamics of cell components as modules rather than isolated part. Progress in technological devices, analytical methods and biological models are required to decipher molecular networks and eventually analyze the cell as a system. Clustering analysis of gene expression profiles allows the analysis of " correlation" between genes and biological conditions. However it is yet restrictive as it does not reveal the causality of regulatory relationships. Besides it is very difficult to infer molecular networks from expression profiling only, as the only accessible information is the steady-state concentration of... Show More


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