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Networking Genes And Drugs: Understanding Gene Function And Drug Mode Of Action From Large-Scale Experimental Data

Networking Genes And Drugs: Understanding Gene Function And Drug Mode Of Action From Large-Scale Experimental Data

This video was recorded at 3rd International Workshop on Machine Learning in Systems Biology (MLSB), Ljubljana 2009. A cell can be described as a synergistic ensemble of biological entities (mRNA, proteins, ncRNA, metabolites, etc) interacting with each other, whose collective behaviour causes the observed phenotypes. A great research effort is ongoing in identifying and mapping the network of interactions among biomolecules in mammalian species. The idea of harnessing this network to understand human diseases at the molecular level, and possibly to find suitable drugs for their treatment, is fascinating but still unfulfilled. We will show how it is possible to harness experimental data on human cells and tissue to identify the gene regulatory networks among tens of thousands of genes, and... Show More
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