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Towards a Polymer Model of Genetic Recombination

Towards a Polymer Model of Genetic Recombination

This video was recorded at Workshop on Practical Inference Methods for Mechanistic Modelling of Biological Systems (PIMMS), Glasgow 2007. Homologous recombination (HR) refers to the shuffling of genetic material during cellular division e.g., meiosis and mitosis, and in response to environmentally-induced genetic damage. HR occurs preferentially over certain regions, and is notably influenced by physical compartmentalization due to chromosome packing. Although a number of experimental techniques exist for identifying such effect they are generally costly and time-consuming. Here we suggest a Bayesian approach to recom- bination with a mechanistic prior such that we may infer posterior distributions for recombination frequencies and efficiencies between regions where experimental data may be absent.


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