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Employing Publicly Available Biological Expert Knowledge from Protein-Protein Interaction Information

Employing Publicly Available Biological Expert Knowledge from Protein-Protein Interaction Information

This video was recorded at 5th IAPR International Conference on Pattern Recognition in Bioinformatics, Nijmegen 2010. Genome wide association studies (GWAS) are now allowing researchers to probe the depths of common complex human diseases, yet few have identified single sequence variants that confer disease susceptibility. As hypothesized, this is due the fact that multiple interacting factors influence clinical endpoint. Given the number of single nucleotide polymorphisms (SNPs) combinations grows exponentially with the number of SNPs being analyzed, computational methods designed to detect these interactions in smaller datasets are thus not applicable. Providing statistical expert knowledge has exhibited an improvement in their performance, and we believe biological expert knowledge to be... Show More

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