Material Detail

Putting Engineering Back in Protein Engineering

Putting Engineering Back in Protein Engineering

This video was recorded at San Francisco Bay Area ACM Data Mining SIG. ProteinGPS, the technology for navigation in protein space, addresses the shortcomings of existing protein engineering paradigms and takes advantage of the last 50 years of development in linear and nonlinear systems optimization. Protein engineering has classically been approached from two diametrically opposed directions: rational design and directed evolution. Rationalism attempts to understand protein structure and function at a complete mechanistic level so that the effect of any modification to the protein can be estimated by calculation from first principles. Directed evolution on the other hand follows the strict empirical tradition and attempts to find a desired solution by testing many many different solutions,... Show More


  • User Rating
  • Comments
  • Learning Exercises
  • Bookmark Collections
  • Course ePortfolios
  • Accessibility Info

More about this material


Log in to participate in the discussions or sign up if you are not already a MERLOT member.