Learning Exercise

Superimpose aligned protein sequences onto a structure

Students use Biology Workbench and Protein Explorer to align either orthologous or paralogous sequences and then superimpose these onto a 3D structure of one member of the protein family.
Course: Bioinformatics, Molecular Biology, Biochemistry
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Protein Explorer became non-operational about 2008. It is replaced with FirstGlance.Jmol.Org (for guided exploration of... see more

Exercise

See link for text.

Audience

Technical Notes

Requires Chimes plug-in to run protein explorer

Requirements

Understanding of biochemistry and molecular biology

Topics

Bioinformatics
Protein Structure
Evolution

Learning Objectives

For students to explore the sequence similarities in orthologs and paralogs