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DNA Hybridization: Southern Blot

DNA Hybridization: Southern Blot

In this activity, by the Concord Consortium's Molecular Literacy project, students "explore partial and complete hybridization, manipulate binding with temperature, and design their own probe." The activity itself is a java-based interactive resource built upon the free, open source Molecular Workbench software. In the activity, students are allowed to explore at their own pace in a digital environment of demonstrations, illustrations, and models they can manipulate. The content of the module is divided into five sections: an Introduction, Hydrogen Bonds, Denaturation and Hybridization, Designing a DNA probe, and Southern Blot. In addition to the activity, visitors will find an overview, a test and rubric, textbooks references, and correlation to AAAS and NSES standards.

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