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Biological pH-Swing Crystallization

Biological pH-Swing Crystallization

The processing of biochemicals and pharmaceuticals is just as important to Chemical Engineering today as petrochemical production and oil refining. Such processing involves operations such as crystallization, ultracentrifugation, membrane filtration, preparative chromatography and several others, all of which have in common the need to separate large from small molecules, or solid from liquid. In all cases, the separations are energy intensive because the desired products are by necessity present in low concentration in a (usually aqueous) solvent.  Of these biological separation operations, crystallization is the most important from a tonnage standpoint; it is commonly employed in the pharmaceutical, chemical and food processing industries. Important biochemical examples include chiral... Show More


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