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Sulfamethoxazole is a broad spectrum antibiotic that acts as a bacteriostatic antibacterial agent. This study was aimed to analyze the effect of Consciousness Energy Healing Treatment (the Trivedi Effect®) on the physicochemical and thermal properties of sulfamethoxazole with the help of advanced analytical techniques. Sulfamethoxazole sample was divided into two parts. Among these, one part received Consciousness Energy Healing Treatment remotely by a well-known Biof-ield Energy Healer, Alice Branton and termed as the treated sample. While the other part did not receive the Consciousness Energy Healing Treatment called a control sample. The study revealed that the particle size values in the treated sample were significantly reduced by 19.71 % (d10), 6.28 % (d50), 5.40 % (d90), and 7.98 % {D (4, 3)}; thus, the specific surface area was significantly increased by 12.63 % compared with the untreated sample. The powder XRD peak intensities and crystallite sizes were altered significantly ranging from -32.49 % to 120.17 % and 0.45 % to 101.86 %, respectively; whereas, the average crystallite size was significantly increased by 33.13 % in the treated sample compared with the con-trol sample. The TGA data reported 8.35 % increase in total weight loss and 19.55 % significant reduction of the residual amount in the treated sample compared with the control sample. The latent heat of fusion was significantly increased by 10.34 % and the degradation temperature along with the corresponding latent heat of decomposition of the treated sample was increased by 5.52 % and 11.16 %, respectively compared with the untreated sample. The Trivedi Effect®-Conscious-ness Energy Healing Treatment might have created a new polymorphic form of sulfamethoxazole which would be better soluble and bioavailable compared with the untreated sample. The Trivedi Effect Treated sulfamethoxazole might be more beneficial for designing more efficacious novel nutraceutical / pharmaceutical formulations for the prevention and treatment of various diseases such as urinary tract infections, ear infections, traveler’s diarrhea, shigellosis, bronchitis, and Pneumocystis jiroveci pneumonia, etc.

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