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The impact of nonsense-mediated mRNA decay on genetic disease, gene
 editing and cancer immunotherapy

The impact of nonsense-mediated mRNA decay on genetic disease, gene
 editing and cancer immunotherapy

Premature termination codons (PTCs) can result in the production of truncated proteins or the degradation of mRNAs by nonsense-mediated mRNA decay (NMD). Which of these outcomes occurs can alter the effect of a mutation, with the engagement of NMD.

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