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The text discusses the challenges of treating glioblastoma multiforme (GBM), a highly lethal cancer of the central nervous system. Patients with GBM have very low survival rates due to the tumor's ability to evade the immune system and its high degree of heterogeneity. Despite these obstacles, virotherapy shows promise in overcoming these challenges by triggering an immune response and directly targeting tumor cells. The review provides an overview of the immune evasion mechanisms of GBM and the recent successes of virotherapies.

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