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This review provides an overview of the current understanding of the blood-brain barrier in both health and disease and emphasizes unanswered questions. The blood vessels that supply the central nervous system have a specialized structure known as the "blood-brain barrier." This barrier tightly regulates the movement of substances between the blood and the brain tissue. It forms during the development of blood vessels and plays a crucial role in maintaining a stable internal environment for the brain. Dysfunction of the blood-brain barrier is linked to various neurological disorders, including multiple sclerosis, stroke, epilepsy, and neurodegenerative diseases like Alzheimer’s. 

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