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Actin Dynamics - Back Door Model

Actin Dynamics - Back Door Model

This site includes pictures and video clips to substantiate the back door model of actin phosphate dissociation. The mechanical properties of the filaments can be altered by actin-binding agents such as the toxin phalloidin from the mushroom "Amanita phalloides". Phalloidin binding to actin has been shown to delay the release of inorganic phosphate after ATP hydrolysis. Conversely, no effect of inorganic phosphate on the phalloidin binding kinetics has been observed. The goal of this research is to resolve this seemingly paradoxical situation by identifying the dissociation pathway of the phosphate.


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