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Actin-myosin crossbridge animation

Actin-myosin crossbridge animation

The actin-myosin crossbridge system is complex, and we are really only speculating on the details in many ways. However, if a picture is worth a thousand words, this one second, 15 frame, animation is worth at least 15 thousand.
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Sandra Keavey
Sandra Keavey (Faculty)
15 years ago
This really demonstrates a concept frequently described with a lot of words that
don't begin to paint a picture students can understand.
Thomas Lonergan
Thomas Lonergan (Faculty)
16 years ago
I use this site to supplement the two-dimensional diagrams of myosin/actin
interactions typically shown in textbooks. I then ask the students to answer a
series of questions about what they saw. Students find it very challenging to
describe events occuring in a three-dimensional animation. Use of this
apaproach can show you who is just memorizing such steps, and who comprehends
the interactions.
Nancy J. Pelaez
Nancy J. Pelaez (Faculty)
16 years ago
I am VERY concerned about the global approval of this model in both the peer
review and the user comment. This model was presented by a plenary speaker at
the Experimental Biology 2001 meeting as an example of a representation that
does not always fit the data about how muscle works. As with most models, this
one has serious limitations and it should not be taught as fact. An alternative
source of information comes from muscle physiologists. Refer to the MERLOT
site called "Video of myosin v movement along actin" and the research group that
presents an alternative model at the bottom of the page at
http://www.mrc-lmb.cam.ac.uk/myosin/motility/XBcycle.html Perhaps students
should be asked to compare and contrast the models to decide which model best
matches what we know about actin-myosin interactions ( a critical thinking
approach that would leave student with a more realistic view to the limits of
our understanding).

Technical Remarks:

The animations at the links listed above are stacks of gif images.
Brenda Wilder
Brenda Wilder (Faculty)
16 years ago
This is an excelent animation. It is something that I can't duplicate in class
without spending the better part of an hour.

Because it is clearly labelled and keyed, student can view and study it on their
own and I can review it in class.

Brenda Wilder
Brenda Wilder (Faculty)
16 years ago
This is an excelent animation. It is something that I can't duplicate in class
without spending the better part of an hour.

Because it is clearly labelled and keyed, student can view and study it on their
own and I can review it in class.

Alison Morrison-Shetlar
17 years ago
Used the module in my introductory biology course for non-majors. Although it
had a touch too much detail for my group of students, they definitely had a
light bulb going on when they saw the interaction of the different components.
Areas of excellence: easy to use and loads easily.
Areas of concern: none

Technical Remarks:

The applet is exceptional, it runs really well when online in the classroom,
maybe not quite so well over modem. The ability to use one of two options to
view it is excellent.
Might be nice to be able to stop it at certain times.