Material Detail
Actin-myosin crossbridge animation
The actin-myosin crossbridge system is complex, and we are really only speculating on the details in many ways. However, if a picture is worth a thousand words, this one second, 15 frame, animation is worth at least 15 thousand.
Quality
-
Peer Review
-
User Rating
- Comments (6) Comments
- Learning Exercises (2) Learning Exercises
- Bookmark Collections (64) Bookmark Collections
- Course ePortfolios (9) Course ePortfolios
- Accessibility Info
More about this material
- Material Type:
- Simulation
- Date Added to MERLOT:
- May 30, 2000
- Date Modified in MERLOT:
- June 22, 2021
- Author:
-
Jeff Sale,
San Diego Supercomputer Center
- Submitter:
-
Jeff Sale
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Comments
Thomas Lonergan (Faculty)
I use this site to supplement the two-dimensional diagrams of myosin/actin
interactions typically shown in textbooks. I then ask the students to answer a
series of questions about what they saw. Students find it very challenging to
describe events occuring in a three-dimensional animation. Use of this
apaproach can show you who is just memorizing such steps, and who comprehends
the interactions.
interactions typically shown in textbooks. I then ask the students to answer a
series of questions about what they saw. Students find it very challenging to
describe events occuring in a three-dimensional animation. Use of this
apaproach can show you who is just memorizing such steps, and who comprehends
the interactions.
Nancy J. Pelaez (Faculty)
I am VERY concerned about the global approval of this model in both the peer
review and the user comment. This model was presented by a plenary speaker at
the Experimental Biology 2001 meeting as an example of a representation that
does not always fit the data about how muscle works. As with most models, this
one has serious limitations and it should not be taught as fact. An alternative
source of information comes from muscle physiologists. Refer to the MERLOT
site called "Video of myosin v movement along actin" and the research group that
presents an alternative model at the bottom of the page at
http://www.mrc-lmb.cam.ac.uk/myosin/motility/XBcycle.html Perhaps students
should be asked to compare and contrast the models to decide which model best
matches what we know about actin-myosin interactions ( a critical thinking
approach that would leave student with a more realistic view to the limits of
our understanding).
review and the user comment. This model was presented by a plenary speaker at
the Experimental Biology 2001 meeting as an example of a representation that
does not always fit the data about how muscle works. As with most models, this
one has serious limitations and it should not be taught as fact. An alternative
source of information comes from muscle physiologists. Refer to the MERLOT
site called "Video of myosin v movement along actin" and the research group that
presents an alternative model at the bottom of the page at
http://www.mrc-lmb.cam.ac.uk/myosin/motility/XBcycle.html Perhaps students
should be asked to compare and contrast the models to decide which model best
matches what we know about actin-myosin interactions ( a critical thinking
approach that would leave student with a more realistic view to the limits of
our understanding).
Technical Remarks:
The animations at the links listed above are stacks of gif images.
Brenda Wilder (Faculty)
This is an excelent animation. It is something that I can't duplicate in class
without spending the better part of an hour.
Because it is clearly labelled and keyed, student can view and study it on their
own and I can review it in class.
without spending the better part of an hour.
Because it is clearly labelled and keyed, student can view and study it on their
own and I can review it in class.
Brenda Wilder (Faculty)
This is an excelent animation. It is something that I can't duplicate in class
without spending the better part of an hour.
Because it is clearly labelled and keyed, student can view and study it on their
own and I can review it in class.
without spending the better part of an hour.
Because it is clearly labelled and keyed, student can view and study it on their
own and I can review it in class.
Alison Morrison-Shetlar (Faculty)
Used the module in my introductory biology course for non-majors. Although it
had a touch too much detail for my group of students, they definitely had a
light bulb going on when they saw the interaction of the different components.
Areas of excellence: easy to use and loads easily.
Areas of concern: none
had a touch too much detail for my group of students, they definitely had a
light bulb going on when they saw the interaction of the different components.
Areas of excellence: easy to use and loads easily.
Areas of concern: none
Technical Remarks:
The applet is exceptional, it runs really well when online in the classroom,
maybe not quite so well over modem. The ability to use one of two options to
view it is excellent.
Might be nice to be able to stop it at certain times.
maybe not quite so well over modem. The ability to use one of two options to
view it is excellent.
Might be nice to be able to stop it at certain times.
Sandra Keavey (Faculty)
don't begin to paint a picture students can understand.