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Formulation of PLGA nanoparticles for intracellular delivery of protein drug

Formulation of PLGA nanoparticles for intracellular delivery of protein drug

This video was recorded at SLONANO conference, Ljubljana 2007. Design and formulation of advanced drug delivery systems (DDS), such as nanoscale carriers, presents an attractive research area in the field of drug formulation. A vast contribution is expected in delivery of biopharmaceuticals as is clearly recognized that inadequate delivery is the single most important factor delaying their application in clinical practise. In spite of some successful guidelines, formulation of protein drugs in DDS requires step-by step strategy and methods differing from those used for classical pharmaceutical drugs since proteins are the most delicate ones in term of retaining their biological function. A model protein drug cystatin was selected in our work, having high potential for inactivating cysteine... Show More
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