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Sulfamethoxazole is the sulfonamide class of antibiotic that acts as a bacteriostatic agent against various bacteria. The current study was aimed to analyze the impact of the Consciousness Energy Healing Treatment (the Trivedi Effect®) on various properties of sulfamethoxazole by using different modern analytical techniques. For this, the sample was first divided into two parts, followed by considering one part as a control sample (no treatment was given). The second part was named as the Biofield Energy Treated sample that was remotely given the Consciousness Energy Healing Treatment by a renowned Biofield Energy Healer, Gopal Nayak. The particle size values were reduced by 14.35%(d10), 8.93%(d50), 7.84%(d90), and 9.24%{D(4,3)}; therefore, the specific surface area was increased by 9.68% in the treated sample compared to the control sample. The PXRD peak intensities and crystallite sizes were significantly altered ranging from -68.71% to 40.38% and -31.58% to 169.60%, respectively; however, the average crystallite size was significantly increased by 9.49% in the treated sample compared to the control sample. The residue weight and maximum thermal degradation temperature were increased by 2.12% and 3.25%, respectively in the treated sample compared with the control sample. The decomposition temperature, latent heat of fusion, and latent heat of decomposition were significantly increased by 11.44%, 48.27%, and 22.59%, respectively in the treated sample compared to the control sample. Thus, the Trivedi Effect®-Consciousness Energy Healing Treated sulfamethoxazole might have formed a new polymorph with reduced particle size and improved surface area and thermal stability. Hence, the use of the treated sulfamethoxazole might be more beneficial in terms of improved solubility, absorption, bioavailability, stability and also for designing the more efficacious pharmaceutical formulations for the treatment and prevention of various bacterial diseases, i.e., ear infections, urinary tract infections, shigellosis, traveler’s diarrhea, bronchitis, and pneumocystis-type of pneumonia, etc.

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