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The blood-brain barrier (BBB) is a crucial semipermeable system in the central nervous system that regulates the transport of essential materials while protecting the brain from harmful substances in the blood. This review explores the cells and components supporting the barrier's function, pathways for molecule transport, dysfunction causes, neuropathological consequences, and potential biomarkers for predicting BBB disturbances. The overview aims to guide future research on developing targeted material delivery systems for combinatorial therapy in conditions like brain tumors and carcinomas.

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