Material Detail

The blood-brain barrier (BBB) is crucial for protecting the brain from toxins and maintaining its homeostasis. When the BBB leaks in conditions like stroke, brain tumors, and neurodegenerative disorders, it leads to serious secondary injuries. Currently, there are no specific drugs to treat BBB damage, but growing knowledge in epigenetics holds promise for the development of novel therapeutic strategies to repair a disrupted BBB. This review highlights epigenetic mechanisms that play protective or disruptive roles in BBB components, along with potential approaches to restore BBB integrity.

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