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By disrupting both the proteins and DNA at one time, it is possible to make it harder for bacteria to evolve resistance. When both are targeted at the same time, neither can have any mutations to protect the other target. Macrolones are a type of antibiotic that attacks both targets. By binding to the ribosomes, macrolones were able to prevent antibiotic-resistance genes from being activated. This has the potential to help get rid of antibiotic resistance. 

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