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Micronuclei and chromosomal aberrations in healthy tobacco chewers and controls: A study from Gujarat, India

Micronuclei and chromosomal aberrations in healthy tobacco chewers and controls: A study from Gujarat, India

Authors: Patel Beena P. --- Trivedi Pina J. --- Brahmbhatt Manisha M. --- Shukla Shilin N. --- et al. Journal: Archive of Oncology ISSN/EISSN: 03547310 14509520 Year: 2009 Volume: 17 Issue: 1-2 Pages: 7-10 DOI: 10.2298/AOO0902007P Abstract Background: Tobacco chewing is attributed to oral cancer. Prediction of cancer development by genotoxicity analysis is a major challenge to identify tobacco users at greater risk. Therefore, present study aimed to analyze tobacco related genotoxic effects in chewers monitoring micronuclei (MN) and chromosome aberrations (CA). The biomarkers were compared with non chewer to (i) predict risk for genotoxicity, (ii) estimate synergistic effect of tobacco exposure with level of biomarkers, and (iii) identify best cellular site of measurements for genotoxicity... Show More
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