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Detection of derivative 9 deletion by BCR-ABL fluorescence in-situ hybridization signal pattern to evaluate treatment response in CML patients

Detection of derivative 9 deletion by BCR-ABL fluorescence in-situ hybridization signal pattern to evaluate treatment response in CML patients

Authors: Patel Beena P. --- Trivedi Pina J. --- Brahmbhatt Manisha M. --- Gajjar Sarju B. --- et al. Journal: Archive of Oncology ISSN/EISSN: 03547310 14509520 Year: 2009 Volume: 17 Issue: 1-2 Pages: 13-18 DOI: 10.2298/AOO0902013P Abstract Background: To evaluate prognostic effect of submicroscopic deletions involving breakage and fusion points of the derivative chromosome 9 and 22 in chronic myeloid leukemia in untreated patients and their follow up samples to correlate with disease outcome. Methods: The study included 78 pretreatment (PT) samples from CML patients and 90 follow-up samples, classified as complete responders (CR, n=33), nonresponders (NR, n =54), and partial responder (PR, n=3) depending on the treatment status of the follow-up samples. Karyotype analysis was performed on... Show More
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